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Article

Recurrent PAX3-MAML3 fusion in biphenotypic sinonasal sarcoma.

Nature genetics - 1 Jul 2014

Wang Xiaoke, Bledsoe Krista L, Graham Rondell P, Asmann Yan W, Viswanatha David S, Lewis Jean E, Lewis Jason T, Chou Margaret M, Yaszemski Michael J, Jen Jin, Westendorf Jennifer J, Oliveira André M

Abstract excerpt

Biphenotypic sinonasal sarcoma (SNS) is a newly described tumor of the nasal and paranasal areas. Here we report a recurrent chromosomal translocation in SNS, t(2;4)(q35;q31.1), resulting in a PAX3-MAML3 fusion protein that is a potent transcriptional activator of PAX3 response elements. The SNS phenotype is characterized by aberrant expression of genes involved in neuroectodermal and myogenic differentiation,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24859338
DOI: 10.1038/ng.2989
PMCID: PMC4236026

Genes

PAX3
MAML3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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