Article
Sequential gastroenteritis episodes caused by 2 norovirus genotypes.
Emerging infectious diseases - 1 Jun 2014
Parra Gabriel I, Green Kim Y
Abstract excerpt
We investigated sequential episodes of acute norovirus gastroenteritis in a young child within an 11-month period. The infections were caused by 2 distinct genotypes (GII.4 and GII.6). Failure to achieve cross-protective immunity was linked to absence of an enduring and cross-reactive mucosal immune response, a critical consideration for vaccine design.
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