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Article

Lowest numbers of primary CD8+ T cells can reconstitute protective immunity upon adoptive immunotherapy

23 May 2014

Abstract excerpt

Patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) are threatened by potentially lethal viral manifestations like cytomegalovirus (CMV) reactivation. Because the success of today's virostatic treatment is limited by side effects and resistance development, adoptive transfer of virus-specific memory T cells derived from the stem cell donor has been proposed as an alternative...

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PMID: 24855206
DOI: 10.1182/blood-2013-12-547349

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