Article
Atmin mediates kidney morphogenesis by modulating Wnt signaling.
Human molecular genetics - 15 Oct 2014
Goggolidou Paraskevi, Hadjirin Nazreen F, Bak Aggie, Papakrivopoulou Eugenia, Hilton Helen, Norris Dominic P, Dean Charlotte H
Abstract excerpt
The DNA damage protein and transcription factor Atmin (Asciz) is required for both lung tubulogenesis and ciliogenesis. Like the lungs, kidneys contain a tubular network that is critical for their function and in addition, renal ciliary dysfunction has been implicated in the pathogenesis of cystic kidney disease. Using the Atmin mouse mutant Gasping6 (Gpg6), we investigated kidney development and found it...
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