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Article

Therapeutic potential of Dickkopf-1 in wild-type BRAF papillary thyroid cancer via regulation of β-catenin/E-cadherin signaling.

The Journal of clinical endocrinology and metabolism - 1 Sept 2014

Cho Sun Wook, Kim Young A, Sun Hyun Jin, Ahn Hwa Young, Lee Eun Kyung, Yi Ka Hee, Oh Byung-Chul, Park Do Joon, Cho Bo Youn, Park Young Joo

Abstract excerpt

BACKGROUND: Aberrant activation of the Wnt/β-catenin pathway is a common pathogenesis of various human cancers. We investigated the role of the Wnt inhibitor, Dkk-1, in papillary thyroid cancer (PTC). METHODS: Immunohistochemical β-catenin staining was performed in tissue microarray containing 148 PTCs and five normal thyroid tissues. In vivo effects of Dkk-1 were explored using ectopic tumors with BHP10-3SC...

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Identifiers

PMID: 24848709
DOI: 10.1210/jc.2013-4467

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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