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Article

New mutations in ADC-type β-lactamases from Acinetobacter spp. affect cefoxitin and ceftazidime hydrolysis.

The Journal of antimicrobial chemotherapy - 1 Sept 2014

Pérez Astrid, Pérez-Llarena Francisco José, García Patricia, Kerff Frédéric, Beceiro Alejandro, Galleni Moreno, Bou Germán

Abstract excerpt

OBJECTIVES: Two natural variants of ADC-type β-lactamases of Acinetobacter spp., ADC-1 and ADC-5, differ by nine mutations in their protein sequence. ADC-5 hydrolyses cefoxitin better than ADC-1 and the opposite is true for ceftazidime. We produced single and combined mutations in ADC-5 and chara...

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Source

Identifiers

PMID: 24845871
DOI: 10.1093/jac/dku163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24845871-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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