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Extended-Spectrum Cephalosporinase in Acinetobacter baumannii

15 Jun 2010

Abstract excerpt

An AmpC-type beta-lactamase conferring high-level resistance to expanded-spectrum cephalosporins and monobactams was characterized from an Acinetobacter baumannii clinical isolate. This class C beta-lactamase (named ADC-33) possessed a Pro210Arg substitution together with a duplication of an Ala residue at position 215 (inside the Omega-loop) compared to a reference AmpC cephalosporinase from A. baumannii. ADC-33...

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PMID: 20547808
DOI: 10.1128/aac.00050-10

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