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Article

Novel strategies to enforce an epithelial phenotype in mesenchymal cells.

Cancer research - 15 Jul 2014

Dragoi Ana-Maria, Swiss Rachel, Gao Beile, Agaisse Hervé

Abstract excerpt

E-cadherin downregulation in cancer cells is associated with epithelial-to-mesenchymal transition (EMT) and metastatic prowess, but the underlying mechanisms are incompletely characterized. In this study, we probed E-cadherin expression at the plasma membrane as a functional assay to identify genes involved in E-cadherin downregulation. The assay was based on the E-cadherin-dependent invasion properties of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24845104
DOI: 10.1158/0008-5472.CAN-13-3231
PMCID: PMC4102654

Genes

ZEB1
CASP7
CAV2
HDAC1
MMP14
PCGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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