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Article

Characterization of a phenotypically and functionally distinct subset of large granular lymphocytes (pit cells) in rat liver sinusoids.

Hepatology (Baltimore, Md.) - 1 Jul 1990

Vanderkerken K, Bouwens L, Wisse E

Abstract excerpt

Pit cells, or large granular lymphocytes, with natural tumoricidal activity are found in the sinusoids of normal rat liver. Hepatic large granular lymphocytes are heterogeneous and can be subdivided into two subsets. These subsets were compared with peripheral-blood large granular lymphocytes and were found to differ phenotypically and functionally. Phenotypical differences included lower expression of the...

Topics

Animals
Cell Line
Cytoplasmic Granules
Cytotoxicity, Immunologic
Killer Cells, Natural
Liver
Lymphocytes
Male
Microscopy, Electron
Phenotype
Rats
Rats, Inbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2373487
DOI: 10.1002/hep.1840120112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2373487-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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