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Article

Development of an interferon-gamma ELISPOT assay to detect human T cell responses to HSV-2.

Vaccine - 16 Sept 2011

Posavad Christine M, Magaret Amalia S, Zhao Lin, Mueller Dawn E, Wald Anna, Corey Lawrence

Abstract excerpt

BACKGROUND: The need for an HSV-2 vaccine is great considering the increasing prevalence of HSV-2 despite the widespread use of antiviral drugs. Human clinical trials of HSV-2 vaccines that elicit neutralizing antibodies have proven to be only partially effective suggesting that induction of effective T cell responses to HSV-2 is also a critical component to an efficacious vaccine. A sensitive and specific assay...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme-Linked Immunospot Assay

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Source

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Identifiers

PMID: 21801778
DOI: 10.1016/j.vaccine.2011.07.028
PMCID: PMC3168963

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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