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Article

Integrated Systems Pharmacology Analysis of Clinical Drug‐Induced Peripheral Neuropathy

1 May 2014

Abstract excerpt

A systems pharmacology approach was undertaken to define and identify the proteins/genes significantly associated with clinical incidence and severity of drug-induced peripheral neuropathy (DIPN). Pharmacological networks of 234 DIPN drugs, their known targets (both intended and unintended), and the intermediator proteins/genes interacting with these drugs via their known targets were examined. A permutation test...

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PMID: 24827872
DOI: 10.1038/psp.2014.11

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