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Assessment of individuals with BRCA1 and BRCA2 large rearrangements in high-risk breast and ovarian cancer families.

Breast cancer research and treatment - 1 Jun 2014

Arnold Angela G, Otegbeye Ebunoluwa, Fleischut Megan Harlan, Glogowski Emily A, Siegel Beth, Boyar Sherry R, Salo-Mullen Erin, Amoroso Kim, Sheehan Margaret, Berliner Janice L, Stadler Zsofia K, Kauff Noah D, Offit Kenneth, Robson Mark E, Zhang Liying

Abstract excerpt

BRCA1/2 large rearrangement (LR) testing has been available to patients since 2006. Three existing models commonly used in cancer genetics clinical and research settings (BRCAPRO, Penn II and Myriad II) have not been assessed for their performance in predicting the presence of BRCA1/2 large genomic rearrangements in patients who do not have mutations detectable by the traditional Sanger sequencing approach. This...

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Identifiers

PMID: 24825132
DOI: 10.1007/s10549-014-2987-6

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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