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Article

Paroxysmal itch caused by gain-of-function Nav1.7 mutation.

Pain - 1 Sept 2014

Devigili Grazia, Eleopra Roberto, Pierro Tiziana, Lombardi Raffaella, Rinaldo Sara, Lettieri Christian, Faber Catharina G, Merkies Ingemar S J, Waxman Stephen G, Lauria Giuseppe

Abstract excerpt

Itch is a common experience. It can occur in the course of systemic diseases and can be a manifestation of allergies or a consequence of diseases affecting the somatosensory pathway. We describe a kindred characterized by paroxysmal itch caused by a variant in SCN9A gene encoding for the Nav1.7 sodium channel. Patients underwent clinical and somatosensory profile assessment by quantitative sensory testing, nerve...

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Identifiers

PMID: 24820863
DOI: 10.1016/j.pain.2014.05.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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