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Article

Frequency of activating mutations in FGFR2 exon 7 in bladder tumors from patients with early-onset and regular-onset disease.

International journal of clinical and experimental pathology - 1 Jan 2014

Spiegelberg Christine, Giedl Johannes, Gaisa Nadine T, Rogler Anja, Riener Marc-Oliver, Filbeck Thomas, Burger Maximilian, Ruemmele Petra, Hartmann Arndt, Stoehr Robert

Abstract excerpt

The FGF/FGFR-system plays an important role in embryogenesis, tissue homeostasis and carcinogenesis. Mutational activation of FGFR2 resulting in aberrant FGFR2 signaling activation is known from both hereditary germ line alterations and somatic mutations in various malignancies (e.g. breast, gastric or ovarian cancer). FGFR2 mutations are mainly located within the hinge between Ig-like domains (exon 7), around...

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Identifiers

PMID: 24817968
PMCID: PMC4014252

Genes

FGFR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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