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Article

U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells.

Cancer medicine - 1 Aug 2014

Torsvik Anja, Stieber Daniel, Enger Per Øyvind, Golebiewska Anna, Molven Anders, Svendsen Agnete, Westermark Bengt, Niclou Simone P, Olsen Thale Kristin, Chekenya Enger Martha, Bjerkvig Rolf

Abstract excerpt

It is well known that in vitro subculture represents a selection pressure on cell lines, and over time this may result in a genetic drift in the cancer cells. In addition, long-term cultures harbor the risk of cross-contamination with other cell lines. The consequences may have major impact on ex...

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PMID: 24810477
DOI: 10.1002/cam4.219
PMCID: PMC4303149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24810477-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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