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Article

Covalent conjugation of a peptide triazole to HIV-1 gp120 enables intramolecular binding site occupancy.

Biochemistry - 3 Jun 2014

Emileh Ali, Duffy Caitlin, Holmes Andrew P, Rosemary Bastian Arangassery, Aneja Rachna, Tuzer Ferit, Rajagopal Srivats, Li Huiyuan, Abrams Cameron F, Chaiken Irwin M

Abstract excerpt

The HIV-1 gp120 glycoprotein is the main viral surface protein responsible for initiation of the entry process and, as such, can be targeted for the development of entry inhibitors. We previously identified a class of broadly active peptide triazole (PT) dual antagonists that inhibit gp120 interactions at both its target receptor and coreceptor binding sites, induce shedding of gp120 from virus particles prior to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24801282
DOI: 10.1021/bi500136f
PMCID: PMC4045323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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