Article
The V1/V2 loop of HIV-1 gp120 is necessary for Tat binding and consequent modulation of virus entry.
FEBS letters - 17 Sept 2013
Cardaci Sabrina, Soster Marco, Bussolino Federico, Marchiò Serena
Abstract excerpt
Preventing cell entry of human immunodeficiency virus 1 (HIV-1) is of interest for the development of innovative therapies. We previously reported a specific interaction between HIV-1 envelope glycoprotein 120 (gp120) and Tat at the cell surface, which enhances virus attachment and entry. We also identified a gp120-mimicking peptide, CT319, that competes with gp120 for Tat binding, thus inhibiting HIV-1...
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