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Article

Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators.

Retrovirology - 9 Oct 2021

Zhang Shiyu, Holmes Andrew P, Dick Alexej, Rashad Adel A, Enríquez Rodríguez Lucía, Canziani Gabriela A, Root Michael J, Chaiken Irwin M

Abstract excerpt

BACKGROUND: We previously developed drug-like peptide triazoles (PTs) that target HIV-1 Envelope (Env) gp120, potently inhibit viral entry, and irreversibly inactivate virions. Here, we investigated potential mechanisms of viral escape from this promising class of HIV-1 entry inhibitors. RESULTS: HIV-1 resistance to cyclic (AAR029b) and linear (KR13) PTs was obtained by dose escalation in viral passaging...

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Share to Anti-HIV Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34627310
DOI: 10.1186/s12977-021-00575-z
PMCID: PMC8501640

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