Article
Association of MMP3 and TIMP2 promoter polymorphisms with nonsyndromic oral clefts.
Birth defects research. Part A, Clinical and molecular teratology - 1 Jul 2012
Letra Ariadne, Silva Renato M, Motta Luise G, Blanton Susan H, Hecht Jacqueline T, Granjeirol Jose M, Vieira Alexandre R
Abstract excerpt
BACKGROUND: Oral clefts are common congenital anomalies and result from defects during embryogenesis. The complex etiology is evident by the number of genes and signaling pathways involved in craniofacial development. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are responsible for tissue remodeling during craniofacial development. METHODS: In this study, we investigated the association of...
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