Expression and secretion of galectin-12 in the context of neutrophilic differentiation of human promyeloblastic HL-60 cells.

doi:10.1002/jcp.31288

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Article

Expression and secretion of galectin-12 in the context of neutrophilic differentiation of human promyeloblastic HL-60 cells.

Journal of cellular physiology - 1 Jun 2024

Tazhitdinova Rada, Cristiano Sara, Yi Joshua, Zhurov Vladimir, DeKoter Rodney P, Timoshenko Alexander V

Abstract excerpt

Galectin-12 is a tissue-specific galectin that has been largely defined by its role in the regulation of adipocyte differentiation and lipogenesis. This study aimed to evaluate the role of galectin-12 in the differentiation and polarization of neutrophils within a model of acute myeloid leukemia HL-60 cells. All-trans retinoic acid and dimethyl sulfoxide were used to induce differentiation of HL-60 cells which...

Topics

Humans
Cell Differentiation
Galectins
HL-60 Cells
Leukemia, Promyelocytic, Acute
Lipid Metabolism
Neutrophils
Phenotype
Tretinoin

Source

Open in PubMed

Identifiers

PMID: 38685860
DOI: 10.1002/jcp.31288

Genes

LGALS12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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