Article
Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jul 2014
Alfaradhi Maria Z, Fernandez-Twinn Denise S, Martin-Gronert Malgorzata S, Musial Barbara, Fowden Abigail, Ozanne Susan E
Abstract excerpt
Changes in the maternal nutritional environment during fetal development can influence offspring's metabolic risk in later life. Animal models have demonstrated that offspring of diet-induced obese dams develop metabolic complications, including nonalcoholic fatty liver disease. In this study we investigated the mechanisms in young offspring that lead to the development of nonalcoholic fatty liver disease...
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