Article
Developmental origins of nonalcoholic fatty liver disease.
Pediatric research - 1 Jan 2014
Brumbaugh David E, Friedman Jacob E
Abstract excerpt
Obese pregnant women may transmit their metabolic phenotype to offspring, leading to a cycle of obesity and diabetes over generations. Early childhood obesity predicts nonalcoholic fatty liver disease (NAFLD), the most common chronic human liver disease. The fetus may be vulnerable to steatosis because immature fetal adipose depots are not available to buffer the excess transplacental lipid delivery in maternal...
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