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Article

Ordered subset analysis of copy number variation association with age at onset of Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2014

Szigeti Kinga, Kellermayer Blanka, Lentini Jenna M, Trummer Brian, Lal Deepika, Doody Rachelle S, Yan Li, Liu Song, Ma Changxing

Abstract excerpt

Genetic heterogeneity is a common problem for genome-wide association studies of complex human diseases. Ordered-subset analysis (OSA) reduces genetic heterogeneity and optimizes the use of phenotypic information, thus improving power under some disease models. We hypothesized that in a genetically heterogeneous disorder such as Alzheimer's disease (AD), utilizing OSA by age at onset (AAO) of AD may increase the...

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Source

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Identifiers

PMID: 24787912
DOI: 10.3233/JAD-132693
PMCID: PMC4866488

Genes

CHRNA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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