Article
Genome-wide scan of copy number variation in late-onset Alzheimer's disease.
Journal of Alzheimer's disease : JAD - 1 Jan 2010
Heinzen Erin L, Need Anna C, Hayden Kathleen M, Chiba-Falek Ornit, Roses Allen D, Strittmatter Warren J, Burke James R, Hulette Christine M, Welsh-Bohmer Kathleen A, Goldstein David B
Abstract excerpt
Alzheimer's disease is a complex and progressive neurodegenerative disease leading to loss of memory, cognitive impairment, and ultimately death. To date, six large-scale genome-wide association studies have been conducted to identify SNPs that influence disease predisposition. These studies have confirmed the well-known APOE epsilon4 risk allele, identified a novel variant that influences disease risk within the...
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