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Article

Pharmacodynamic and pharmacogenomic study of the nanoparticle conjugate of camptothecin CRLX101 for the treatment of cancer.

Nanomedicine : nanotechnology, biology, and medicine - 1 Oct 2014

Gaur Shikha, Wang Yafan, Kretzner Leo, Chen Linling, Yen Terence, Wu Xiwei, Yuan Yate-Ching, Davis Mark, Yen Yun

Abstract excerpt

CRLX101 is a nanopharmaceutical consisting of cyclodextrin-based polymer molecule and camptothecin. The CRLX101 nanoparticle is designed to concentrate and slowly release camptothecin in tumors over an extended period of time. Tumor biopsy and blood samples collected from patients with advanced s...

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Source

Identifiers

PMID: 24768630
DOI: 10.1016/j.nano.2014.04.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24768630-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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