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Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy

8 Sept 2020

Abstract excerpt

Covering: up to 2020As a main bioactive component of the Chinese, Indian, and American Podophyllum species, the herbal medicine, podophyllotoxin (PTOX) exhibits broad spectrum pharmacological activity, such as superior antitumor activity and against multiple viruses. PTOX derivatives (PTOXs) could arrest the cell cycle, block the transitorily generated DNA/RNA breaks, and blunt the growth-stimulation by targeting...

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PMID: 32895676
DOI: 10.1039/d0np00041h

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