Article
The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal.
Science (New York, N.Y.) - 9 May 2014
Rosas Marcela, Davies Luke C, Giles Peter J, Liao Chia-Te, Kharfan Bashar, Stone Timothy C, O'Donnell Valerie B, Fraser Donald J, Jones Simon A, Taylor Philip R
Abstract excerpt
Tissue-resident macrophages are heterogeneous as a consequence of anatomical niche-specific functions. Many populations self-renew independently of bone marrow in the adult, but the molecular mechanisms of this are poorly understood. We determined a transcriptional profile for the major self-renewing population of peritoneal macrophages in mice. These cells specifically expressed the transcription factor Gata6....
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