Article
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages.
Nature immunology - 1 Nov 2012
Gautier Emmanuel L, Shay Tal, Miller Jennifer, Greter Melanie, Jakubzick Claudia, Ivanov Stoyan, Helft Julie, Chow Andrew, Elpek Kutlu G, Gordonov Simon, Mazloom Amin R, Ma'ayan Avi, Chua Wei-Jen, Hansen Ted H, Turley Shannon J, Merad Miriam, Randolph Gwendalyn J
Abstract excerpt
We assessed gene expression in tissue macrophages from various mouse organs. The diversity in gene expression among different populations of macrophages was considerable. Only a few hundred mRNA transcripts were selectively expressed by macrophages rather than dendritic cells, and many of these were not present in all macrophages. Nonetheless, well-characterized surface markers, including MerTK and FcγR1 (CD64),...
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