Polymorphisms in the GNAS Gene as Predictors of Ventricular Tachyarrhythmias and Sudden Cardiac Death: Results From the DISCOVERY Trial and Oregon Sudden Unexpected Death Study.

doi:10.1161/JAHA.116.003905

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Polymorphisms in the GNAS Gene as Predictors of Ventricular Tachyarrhythmias and Sudden Cardiac Death: Results From the DISCOVERY Trial and Oregon Sudden Unexpected Death Study.

Journal of the American Heart Association - 28 Nov 2016

Wieneke Heinrich, Svendsen Jesper Hastrup, Lande Jeffrey, Spencker Sebastian, Martinez Juan Gabriel, Strohmer Bernhard, Toivonen Lauri, Le Marec Hervé, Garcia-Fernandez F Javier, Corrado Domenico, Huertas-Vazquez Adriana, Uy-Evanado Audrey, Rusinaru Carmen, Reinier Kyndaron, Foldesi Csaba, Hulak Wieslaw, Chugh Sumeet S, Siffert Winfried

Abstract excerpt

BACKGROUND: Population-based studies suggest that genetic factors contribute to sudden cardiac death (SCD). METHODS AND RESULTS: In the first part of the present study (Diagnostic Data Influence on Disease Management and Relation of Genetic Polymorphisms to Ventricular Tachy-arrhythmia in ICD Patients [DISCOVERY] trial) Cox regression was done to determine if 7 single-nucleotide polymorphisms (SNPs) in 3 genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromogranins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Death, Sudden, Cardiac

Share to Defibrillators, Implantable

Share to GTP-Binding Protein alpha Subunits, Gs

Share to Heart Failure

Share to Proportional Hazards Models

Share to Tachycardia, Ventricular

Share to Ventricular Fibrillation

Source

Open in PubMed Open full text

Identifiers

PMID: 27895044
DOI: 10.1161/JAHA.116.003905
PMCID: PMC5210425

Genes

GNAS
SCD
GNAQ
GNB3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in the GNAS Gene as Predictors of Ventricular Tachyarrhythmias and Sudden Cardiac Death: Results From the DISCOVERY Trial and Oregon Sudden Unexpected Death Study.PMID 27895044Read ↗

Genetic Causes of Sudden Cardiac Arrest in the CommunitySemantic proximity Read ↗

Population-Based Analysis of Rare Genetic Variants in Sudden Cardiac Arrest.Semantic proximity Read ↗

A novel tool for arrhythmic risk stratification in desmoplakin gene variant carriersSemantic proximity Read ↗

Evaluation of gene validity for CPVT and short QT syndrome in sudden arrhythmic deathSemantic proximity Read ↗

Common variants in CASQ2, GPD1L, and NOS1AP are significantly associated with risk of sudden death in patients with coronary artery disease.Semantic proximity Read ↗

Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest.Semantic proximity Read ↗

Common genetic variants associated with sudden cardiac death: the FinSCDgen study.Semantic proximity Read ↗

A common missense variant in the neuregulin 1 gene is associated with both schizophrenia and sudden cardiac death.Semantic proximity Read ↗

Catecholaminergic polymorphic ventricular tachycardia patients with multiple genetic variants in the PACES CPVT RegistrySemantic proximity Read ↗

Correlation analysis between GNAS2 gene polymorphisms in children with arrhythmia.Semantic proximity Read ↗

Epidemiology and stratification of risk for sudden cardiac death.Semantic proximity Read ↗

Novel loci associated with increased risk of sudden cardiac death in the context of coronary artery disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.