Article
Dystroglycan mediates homeostatic synaptic plasticity at GABAergic synapses.
Proceedings of the National Academy of Sciences of the United States of America - 6 May 2014
Pribiag Horia, Peng Huashan, Shah Waris Ali, Stellwagen David, Carbonetto Salvatore
Abstract excerpt
Dystroglycan (DG), a cell adhesion molecule well known to be essential for skeletal muscle integrity and formation of neuromuscular synapses, is also present at inhibitory synapses in the central nervous system. Mutations that affect DG function not only result in muscular dystrophies, but also in severe cognitive deficits and epilepsy. Here we demonstrate a role of DG during activity-dependent homeostatic...
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