Article
PCR for detection of oseltamivir resistance mutation in influenza A(H7N9) virus.
Emerging infectious diseases - 1 May 2014
Wang Wei, Song Zhigang, Guan Wencai, Liu Yi, Zhang Xiaonan, Xu Lei, Li Jianhua, Yuan Zhenghong, Hu Yunwen
Abstract excerpt
Sensitive molecular techniques are needed for rapid detection of the R292K oseltamivir-resistant mutant of influenza A(H7/N9) virus strain to monitor its transmission and guide antiviral treatment. We developed a real-time reverse transcription PCR and single nucleotide polymorphism probes to differentiate this mutant strain in mixed virus populations in human specimens.
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