Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3.

Cell reports - 10 Apr 2014

Sun Chong, Hobor Sebastijan, Bertotti Andrea, Zecchin Davide, Huang Sidong, Galimi Francesco, Cottino Francesca, Prahallad Anirudh, Grernrum Wipawadee, Tzani Anna, Schlicker Andreas, Wessels Lodewyk F A, Smit Egbert F, Thunnissen Erik, Halonen Pasi, Lieftink Cor, Beijersbergen Roderick L, Di Nicolantonio Federica, Bardelli Alberto, Trusolino Livio, Bernards Rene

Abstract excerpt

There are no effective therapies for the ~30% of human malignancies with mutant RAS oncogenes. Using a kinome-centered synthetic lethality screen, we find that suppression of the ERBB3 receptor tyrosine kinase sensitizes KRAS mutant lung and colon cancer cells to MEK inhibitors. We show that MEK inhibition results in MYC-dependent transcriptional upregulation of ERBB3, which is responsible for intrinsic drug...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Synergism

Share to MAP Kinase Kinase Kinases

Share to Mice, Nude

Share to ras Proteins

Share to Receptor, ErbB-2

Share to Receptor, ErbB-3

Share to Xenograft Model Antitumor Assays

Source

Identifiers

PMID: 24685132
DOI: 10.1016/j.celrep.2014.02.045

Genes

ERBB3
KRAS
BAD
EGFR
ERBB2
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3.PMID 24685132Read ↗

RAF suppression synergizes with MEK inhibition in KRAS mutant cancer cells.Semantic proximity Read ↗

Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells.Semantic proximity Read ↗

A combinatorial strategy for treating KRAS-mutant lung cancer.Semantic proximity Read ↗

The ERBB network facilitates KRAS-driven lung tumorigenesis.Semantic proximity Read ↗

A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution.Semantic proximity Read ↗

KRAS mutant lung cancer cells are differentially responsive to MEK inhibitor due to AKT or STAT3 activation: implication for combinatorial approach.Semantic proximity Read ↗

Proliferation of colorectal cancer is promoted by two signaling transduction expression patterns: ErbB2/ErbB3/AKT and MET/ErbB3/MAPK.Semantic proximity Read ↗

The ERBB network facilitates KRAS-driven lung tumorigenesisSemantic proximity Read ↗

Synergistic activity and heterogeneous acquired resistance of combined MDM2 and MEK inhibition in KRAS mutant cancers.Semantic proximity Read ↗

Co-targeting KRASG12D and the HER family is efficacious in colorectal cancer.Semantic proximity Read ↗

SIGNATURE-DRIVEN REPURPOSING OF MIDOSTAURIN FOR COMBINATION WITH MEK1/2 AND KRASG12C INHIBITORS IN LUNG CANCERSemantic proximity Read ↗

MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.