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Article

Evolving Hox activity profiles govern diversity in locomotor systems.

Developmental cell - 28 Apr 2014

Jung Heekyung, Mazzoni Esteban O, Soshnikova Natalia, Hanley Olivia, Venkatesh Byrappa, Duboule Denis, Dasen Jeremy S

Abstract excerpt

The emergence of limb-driven locomotor behaviors was a key event in the evolution of vertebrates and fostered the transition from aquatic to terrestrial life. We show that the generation of limb-projecting lateral motor column (LMC) neurons in mice relies on a transcriptional autoregulatory module initiated via transient activity of multiple genes within the HoxA and HoxC clusters. Repression of this module at...

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Identifiers

PMID: 24746670
DOI: 10.1016/j.devcel.2014.03.008
PMCID: PMC4024207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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