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Article

APOE ε2 allele may decrease the age at onset in patients with spinocerebellar ataxia type 3 or Machado-Joseph disease from the Chinese Han population.

Neurobiology of aging - 1 Sept 2014

Peng Huirong, Wang Chunrong, Chen Zhao, Sun Zhanfang, Jiao Bin, Li Kai, Huang Fengzhen, Hou Xuan, Wang Junling, Shen Lu, Xia Kun, Tang Beisha, Jiang Hong

Abstract excerpt

Polymorphism of the apolipoprotein E (APOE) gene has been defined as a modifying factor for age at onset (AO) in neurodegenerative disorders. The AO of spinocerebellar ataxia type 3 or Machado-Joseph disease (SCA3 or MJD) is inversely correlated with expanded CAG repeat lengths in the ATXN3 gene; however, AO is only partially explained by the expanded CAG repeats. We performed a case-control study to explore...

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Source

Identifiers

PMID: 24746364
DOI: 10.1016/j.neurobiolaging.2014.03.020

Genes

APOE
ATXN3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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APOE ε2 allele may decrease the age at onset in patients with spinocerebellar ataxia type 3 or Machado-Joseph disease from the Chinese Han population.PMID 24746364Read ↗

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Two novel SNPs in ATXN3 3' UTR may decrease age at onset of SCA3/MJD in Chinese patients.Semantic proximity Read ↗

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The APOE ε2 allele increases the risk of earlier age at onset in Machado-Joseph disease.Semantic proximity Read ↗

Genome-wide association study identifies genetic factors that modify age at onset in Machado-Joseph disease.Semantic proximity Read ↗

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