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Article

The APOE ε2 allele increases the risk of earlier age at onset in Machado-Joseph disease.

Archives of neurology - 1 Dec 2011

Bettencourt Conceição, Raposo Mafalda, Kazachkova Nadiya, Cymbron Teresa, Santos Cristina, Kay Teresa, Vasconcelos João, Maciel Patrícia, Donis Karina C, Saraiva-Pereira Maria Luiza, Jardim Laura B, Sequeiros Jorge, Lima Manuela

Abstract excerpt

OBJECTIVE: To investigate a modulating effect of the apolipoprotein E (APOE) polymorphism on age at onset of Machado-Joseph disease (MJD). DESIGN: We collected blood samples from 192 patients with MJD and typed the APOE polymorphism. Patients The 192 patients with MJD included 59 from the Azores, 73 from mainland Portugal, and 60 from Brazil. SETTING: Academic research center. RESULTS: Cases with the ε2/ε3...

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Source

Identifiers

PMID: 22159055
DOI: 10.1001/archneurol.2011.636

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The APOE ε2 allele increases the risk of earlier age at onset in Machado-Joseph disease.PMID 22159055Read ↗

The role of apolipoprotein E as a risk factor for an earlier age at onset for Machado-Joseph disease is doubtful.Semantic proximity Read ↗

APOE ε2 allele may decrease the age at onset in patients with spinocerebellar ataxia type 3 or Machado-Joseph disease from the Chinese Han population.Semantic proximity Read ↗

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Genome-wide association study identifies genetic factors that modify age at onset in Machado-Joseph disease.Semantic proximity Read ↗

Genome-wide association study identifies genetic factors that modify age at onset in Machado-Joseph diseaseSemantic proximity Read ↗

Natural selection at the MJD locus: phenotypic diversity, survival and fertility among Machado-Joseph Disease patients from the Azores.Semantic proximity Read ↗

Normal ATXN3 Allele but Not CHIP Polymorphisms Modulates Age at Onset in Machado–Joseph DiseaseSemantic proximity Read ↗

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