Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of P2Y12 gene promoter DNA methylation with the risk of clopidogrel resistance in coronary artery disease patients.

BioMed research international - 1 Jan 2014

Su Jia, Li Xiaojing, Yu Qinglin, Liu Yahui, Wang Yaqing, Song Haojun, Cui Hanbin, Du Weiping, Fei Xiaohong, Liu Junsong, Lin Shaoyi, Wang Jian, Zheng Wenyuan, Zhong Jinyan, Zhang Lulu, Tong Maoqing, Xu Jin, Chen Xiaomin

Abstract excerpt

BACKGROUND: Clopidogrel inhibits the ADP receptor P2Y12 to keep down the platelet aggregation. The goal of our study is to investigate the contribution of P2Y12 promoter DNA methylation to the risk of clopidogrel resistance (CR). METHODS: The platelet functions were measured by the VerifyNow P2Y1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clopidogrel
Share to Coronary Artery Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Drug Resistance

Share to Purinergic P2Y Receptor Antagonists

Share to Receptors, Purinergic P2Y12

Share to Ticlopidine

Share to Treatment Failure

Source

Open in PubMed Open full text

Identifiers

PMID: 24745016
DOI: 10.1155/2014/450814
PMCID: PMC3976931

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24745016-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of P2Y12 gene promoter DNA methylation with the risk of clopidogrel resistance in coronary artery disease patients.PMID 24745016Read ↗

The risk of clopidogrel resistance is associated with ABCB1 polymorphisms but not promoter methylation in a Chinese Han population.Semantic proximity Read ↗

The effect of Xuefu Zhuyu decoction on clopidogrel resistance and its association with the P2Y12 Gene polymorphisms and promoter DNA methylation.Semantic proximity Read ↗

Influence of Genetic and Epigenetic Factors of P2Y12 Receptor on the Safety and Efficacy of Antiplatelet DrugsSemantic proximity Read ↗

Effects of PON1 Gene Promoter DNA Methylation and Genetic Variations on the Clinical Outcomes of Dual Antiplatelet Therapy for Patients Undergoing Percutaneous Coronary Intervention.Semantic proximity Read ↗

The influence of P2Y12 gene polymorphisms on clopidogrel therapy in patients after percutaneous coronary intervention.Semantic proximity Read ↗

Increase in the risk of clopidogrel resistance and consequent TIMI flow impairment by DNA hypomethylation of CYP2C19 gene in STEMI patients undergoing primary percutaneous coronary intervention (PPCI)Semantic proximity Read ↗

Associations of P2Y12R gene polymorphisms with susceptibility to coronary heart disease and clinical efficacy of antiplatelet treatment with clopidogrel.Semantic proximity Read ↗

Association between P2RY12 gene polymorphisms and adverse clinical events in coronary artery disease patients treated with clopidogrel: A systematic review and meta-analysis.Semantic proximity Read ↗

Study of the Association of PEAR1, P2Y12, and UGT2A1 Polymorphisms with Platelet Reactivity in Response to Dual Antiplatelet Therapy in Chinese Patients.Semantic proximity Read ↗

Influence of Genetic Polymorphisms in P2Y12 Receptor Signaling Pathway on Antiplatelet Response to Clopidogrel in Coronary Heart DiseaseSemantic proximity Read ↗

P2Y12 receptor gene polymorphism and the risk of resistance to clopidogrel: A meta-analysis and review of the literature.Semantic proximity Read ↗

Molecular genomic and epigenomic characteristics related to aspirin and clopidogrel resistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.