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Article

Developmental Patterns of Sleep Slow Wave Activity and Synaptic Density in Adolescent Mice

31 Mar 2014

Abstract excerpt

STUDY OBJECTIVE: In humans sleep slow wave activity (SWA) declines during adolescence. It has been suggested that this decline reflects the elimination of cortical synapses, but this hypothesis has never been tested directly. DESIGN: We focused on mouse frontal cortex and collected data from early adolescence (∼postnatal day 20, P20) to adulthood (P60) of (1) SWA; (2) expression of synapsin I, a presynaptic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24744454
DOI: 10.5665/sleep.3570

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