Performance of p16INK4a/Ki-67 immunocytochemistry for identifying CIN2+ in atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion specimens: a Japanese Gynecologic Oncology Group study.

doi:10.1007/s10147-014-0688-0

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Article

Performance of p16INK4a/Ki-67 immunocytochemistry for identifying CIN2+ in atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion specimens: a Japanese Gynecologic Oncology Group study.

International journal of clinical oncology - 1 Feb 2015

Fujii Takuma, Saito Miyuki, Hasegawa Toshihiko, Iwata Takashi, Kuramoto Hiroyuki, Kubushiro Kaneyuki, Ohmura Mineo, Ochiai Kazunori, Arai Hiroharu, Sakamoto Masaru, Motoyama Teiichi, Aoki Daisuke

Abstract excerpt

BACKGROUND: p16(INK4a) immunohistochemistry has revealed a high rate of positivity in cervical intraepithelial neoplasia grade 2 (CIN2) and more severe conditions (CIN2+). The Lower Anogenital Squamous Terminology Standardization project proposed p16(INK4a) immunohistochemistry as an ancillary test for CIN. Immunocytochemistry involving dual staining for p16(INK4a) and Ki-67 in the triage of atypical squamous...

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PMID: 24744261
DOI: 10.1007/s10147-014-0688-0

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