Article
Identifying stem cell gene expression patterns and phenotypic networks with AutoSOME.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014
Newman Aaron M, Cooper James B
Abstract excerpt
Stem cells have the unique property of differentiation and self-renewal and play critical roles in normal development, tissue repair, and disease. To promote systems-wide analysis of cells and tissues, we developed AutoSOME, a machine-learning method for identifying coordinated gene expression patterns and correlated cellular phenotypes in whole-transcriptome data, without prior knowledge of cluster number or...
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