Article
Quantitative imaging of airway liquid absorption in cystic fibrosis.
The European respiratory journal - 1 Sept 2014
Locke Landon W, Myerburg Michael M, Markovetz Matthew R, Parker Robert S, Weber Lawrence, Czachowski Michael R, Harding Thomas J, Brown Stefanie L, Nero Joseph A, Pilewski Joseph M, Corcoran Timothy E
Abstract excerpt
New measures are needed to rapidly assess emerging treatments for cystic fibrosis (CF) lung disease. Using an imaging approach, we evaluated the absorptive clearance of the radiolabeled small molecule probe diethylene triamine penta-acetic acid (DTPA) as an in vivo indicator of changes in airway liquid absorption. DTPA absorption and mucociliary clearance rates were measured in 21 patients with CF (12 adults and...
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