Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional fluorescently labeled bithiazole ΔF508-CFTR corrector imaged in whole body slices in mice.

Bioconjugate chemistry - 21 Dec 2011

Davison Holly R, Taylor Stephanie, Drake Chris, Phuan Puay-Wah, Derichs Nico, Yao Chenjuan, Jones Ella F, Sutcliffe Julie, Verkman A S, Kurth Mark J

Abstract excerpt

We previously reported the identification and structure-activity analysis of bithiazole-based correctors of defective cellular processing of the cystic fibrosis-causing CFTR mutant, ΔF508-CFTR. Here, we report the synthesis and uptake of a functional, fluorescently labeled bithiazole corrector. Following synthesis and functional analysis of four bithiazole-fluorophore conjugates, we found that 5, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Boron Compounds
Share to Cystic Fibrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Share to Fluorescent Dyes

Share to CFTR gene

Share to Mutation

Share to Thiazoles

Source

Open in PubMed Open full text

Identifiers

PMID: 22034937
DOI: 10.1021/bc2004457
PMCID: PMC3245868

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional fluorescently labeled bithiazole ΔF508-CFTR corrector imaged in whole body slices in mice.PMID 22034937Read ↗

Constrained bithiazoles: small molecule correctors of defective ΔF508-CFTR protein trafficking.Semantic proximity Read ↗

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.Semantic proximity Read ↗

A Novel, Uniquely Efficacious Type of CFTR Corrector with Complementary Mode of ActionSemantic proximity Read ↗

Targeting of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein with a Technetium-99m Imaging Probe.Semantic proximity Read ↗

A uniquely efficacious type of CFTR corrector with complementary mode of action.Semantic proximity Read ↗

Simple image-based no-wash method for quantitative detection of surface expressed CFTR.Semantic proximity Read ↗

Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.Semantic proximity Read ↗

Evaluation of Fused Pyrrolothiazole Systems as Correctors of Mutant CFTR Protein.Semantic proximity Read ↗

Highly Selective Artificial K+ Transporters Reverse Liver Fibrosis In VivoSemantic proximity Read ↗

Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5.Semantic proximity Read ↗

Novel Corrector for Variants of SLC6A8: A Therapeutic Opportunity for Creatine Transporter Deficiency.Semantic proximity Read ↗

Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high-affinity inhibitors of cystic fibrosis transmembrane conductance regulator chloride channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.