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Article

RNA polymerase II large subunit is cleaved by caspases during DNA damage-induced apoptosis.

Biochemical and biophysical research communications - 30 Aug 2002

Lu Yi, Luo Zhonghui, Bregman David B

Abstract excerpt

UV radiation induces DNA lesions that are repaired by the nucleotide excision repair (NER) pathway. Cells that are NER deficient such as those derived from xeroderma pigmentosum (XP) patients are susceptible to apoptosis after 10J/m(2) UV radiation, a dose largely survivable by repair proficient cells. Herein, we report that RNA polymerase II large subunit (RNAP II-LS) undergoes caspase-mediated cleavage,...

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PMID: 12200141
DOI: 10.1016/s0006-291x(02)02028-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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