Article
Familial colorectal cancer type X: genetic profiles and phenotypic features.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2015
Dominguez-Valentin Mev, Therkildsen Christina, Da Silva Sabrina, Nilbert Mef
Abstract excerpt
Heredity is a major cause of colorectal cancer, but although several rare high-risk syndromes have been linked to disease-predisposing mutations, the genetic mechanisms are undetermined in the majority of families suspected of hereditary cancer. We review the clinical presentation, histopathologic features, and the genetic and epigenetic profiles of the familial colorectal cancer type X (FCCTX) syndrome with the...
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