Article
Insights into desmosome biology from inherited human skin disease and cardiocutaneous syndromes.
Cell communication & adhesion - 1 Jun 2014
Nitoiu Daniela, Etheridge Sarah L, Kelsell David P
Abstract excerpt
The importance of desmosomes in tissue homeostasis is highlighted by natural and engineered mutations in desmosomal genes, which compromise the skin or heart and in some instances both. Desmosomal gene mutations account for 45-50% of cases of arrhythmogenic right ventricular cardiomyopathy, and are mutated in an array of other disorders such as striate palmoplantar keratoderma, hypotrichosis with or without skin...
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