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Article

The pre-eclampsia gene STOX1 controls a conserved pathway in placenta and brain upregulated in late-onset Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

van Dijk Marie, van Bezu Jan, Poutsma Ankie, Veerhuis Robert, Rozemuller Annemieke J, Scheper Wiep, Blankenstein Marinus A, Oudejans Cees B

Abstract excerpt

Pre-eclampsia and late-onset Alzheimer's disease (LOAD) share no clinical features. In contrast to these clinical dissimilarities, striking parallels exist between the (epi)genetic features associated with pre-eclampsia and LOAD for the genes located on 10q22. The parallels in identity between the 10q22 genes involved and active in the organs (placenta, brain) primarily affected in the respective diseases led us...

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Source

Identifiers

PMID: 20110611
DOI: 10.3233/JAD-2010-1265

Genes

STOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The pre-eclampsia gene STOX1 controls a conserved pathway in placenta and brain upregulated in late-onset Alzheimer's disease.PMID 20110611Read ↗

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Nitroso-Redox Balance and Mitochondrial Homeostasis Are Regulated by <i>STOX1</i> , a Pre-Eclampsia-Associated GeneSemantic proximity Read ↗

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Re-evaluation of the role of STOX1 transcription factor in placental development and preeclampsia.Semantic proximity Read ↗

Direct Downregulation of CNTNAP2 by STOX1A is Associated with Alzheimer's DiseaseSemantic proximity Read ↗

Functional Evaluation of STOX1 (STORKHEAD-BOX PROTEIN 1) in Placentation, Preeclampsia, and Preterm Birth.Semantic proximity Read ↗

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Genetic aspects of preeclampsia.Semantic proximity Read ↗

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Endothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsiaSemantic proximity Read ↗

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