Functional Evaluation of STOX1 (STORKHEAD-BOX PROTEIN 1) in Placentation, Preeclampsia, and Preterm Birth.

doi:10.1161/HYPERTENSIONAHA.120.15619

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Article

Functional Evaluation of STOX1 (STORKHEAD-BOX PROTEIN 1) in Placentation, Preeclampsia, and Preterm Birth.

Hypertension (Dallas, Tex. : 1979) - 1 Feb 2021

Dunk Caroline E, van Dijk Marie, Choudhury Ruhul, Wright Thomas J, Cox Brian, Leavey Katherine, Harris Lynda K, Jones Rebecca L, Lye Stephen J

Abstract excerpt

Revaluation of the association of the STOX1 (STORKHEAD_BOX1 PROTEIN 1) transcription factor mutation (Y153H, C allele) with the early utero-vascular origins of placental pathology is warranted. To investigate if placental STOX1 Y153H genotype affects utero-vascular remodeling-compromised in both preterm birth and preeclampsia-we utilized extravillous trophoblast (EVT) explant and placental decidual coculture...

Topics

Adolescent
Adult
Alleles
Carrier Proteins
Cell Line
Female
Humans
Infant, Newborn
Interleukin-6
Interleukin-8
Placenta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Placentation

Pre-Eclampsia

Pregnancy

Pregnancy Trimester, First

Premature Birth

Trophoblasts

Young Adult

Source

Open in PubMed

Identifiers

PMID: 33356399
DOI: 10.1161/HYPERTENSIONAHA.120.15619

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Functional Evaluation of STOX1 (STORKHEAD-BOX PROTEIN 1) in Placentation, Preeclampsia, and Preterm Birth.PMID 33356399Read ↗

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Nitroso-Redox Balance and Mitochondrial Homeostasis Are Regulated by <i>STOX1</i> , a Pre-Eclampsia-Associated GeneSemantic proximity Read ↗

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STOX1 Overexpression in Choriocarcinoma Cells Mimics Transcriptional Alterations Observed in Preeclamptic PlacentasSemantic proximity Read ↗

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