Article
The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation.
Human molecular genetics - 1 Jul 2010
van Dijk Marie, van Bezu Jan, van Abel Daan, Dunk Caroline, Blankenstein Marinus A, Oudejans Cees B M, Lye Stephen J
Abstract excerpt
By using complementary in vitro and ex vivo approaches, we show that the risk allele (Y153H) of the pre-eclampsia susceptibility gene STOX1 negatively regulates trophoblast invasion by upregulation of the cell-cell adhesion protein alpha-T-catenin (CTNNA3). This is effectuated at the crucial epit...
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