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Differences In The Alveolar Macrophage Proteome In Transgenic Mice Expressing Human SP-A1 And SP-A2

19 Jul 2013

Abstract excerpt

, and evidence indicates that the function of SP-A1 and SP-A2 proteins differ in several respects. To investigate the impact of SP-A1 and SP-A2 on the alveolar macrophage (AM) phenotype, we generated humanized transgenic (hTG) mice on the SP-A knockout (KO) background, each expressing human SP-A1 or SP-A2. Using two-dimensional difference gel electrophoresis (2D-DIGE) we studied the AM cellular proteome. We...

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PMID: 24729982
DOI: 10.14302/issn.2326-0793.jpgr-13-207

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