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Article

nNOS inhibition during profound asphyxia reduces seizure burden and improves survival of striatal phenotypic neurons in preterm fetal sheep.

Neuropharmacology - 1 Aug 2014

Drury Paul P, Davidson Joanne O, Mathai Sam, van den Heuij Lotte G, Ji Haitao, Bennet Laura, Tan Sidhartha, Silverman Richard B, Gunn Alistair J

Abstract excerpt

Basal ganglia injury after hypoxia-ischemia remains common in preterm infants, and is closely associated with later cerebral palsy. In the present study we tested the hypothesis that a highly selective neuronal nitric oxide synthase (nNOS) inhibitor, JI-10, would improve survival of striatal phen...

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Identifiers

PMID: 24726307
DOI: 10.1016/j.neuropharm.2014.03.017
PMCID: PMC4077724

Genes

NPY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24726307-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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