Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

nNOS inhibition during profound asphyxia reduces seizure burden and improves survival of striatal phenotypic neurons in preterm fetal sheep.

Neuropharmacology - 1 Aug 2014

Drury Paul P, Davidson Joanne O, Mathai Sam, van den Heuij Lotte G, Ji Haitao, Bennet Laura, Tan Sidhartha, Silverman Richard B, Gunn Alistair J

Abstract excerpt

Basal ganglia injury after hypoxia-ischemia remains common in preterm infants, and is closely associated with later cerebral palsy. In the present study we tested the hypothesis that a highly selective neuronal nitric oxide synthase (nNOS) inhibitor, JI-10, would improve survival of striatal phenotypic neurons after profound asphyxia, and that the subsequent seizure burden and recovery of EEG are associated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminopyridines
Share to Corpus Striatum

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hypoxia-Ischemia, Brain

Share to Neuroprotective Agents

Share to Nitric Oxide Synthase Type I

Share to Premature Birth

Share to Seizures

Source

Open in PubMed Open full text

Identifiers

PMID: 24726307
DOI: 10.1016/j.neuropharm.2014.03.017
PMCID: PMC4077724

Genes

NPY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

nNOS inhibition during profound asphyxia reduces seizure burden and improves survival of striatal phenotypic neurons in preterm fetal sheep.PMID 24726307Read ↗

Induced cerebral hypothermia reduces post-hypoxic loss of phenotypic striatal neurons in preterm fetal sheep.Semantic proximity Read ↗

Selective neuroprotective effects with insulin-like growth factor-1 in phenotypic striatal neurons following ischemic brain injury in fetal sheep.Semantic proximity Read ↗

Current Evidence on Cell Death in Preterm Brain Injury in Human and Preclinical ModelsSemantic proximity Read ↗

Magnesium Sulphate in Neonatal Hypoxic-Ischemic Encephalopathy: Bridging the Gap Between Molecular Neuroprotection and Clinical OutcomesSemantic proximity Read ↗

Type-I nNOS neurons orchestrate cortical neural activity and vasomotionSemantic proximity Read ↗

New Insights into Epileptic Spasm Generation and Treatment from the TTX Animal ModelSemantic proximity Read ↗

Perinatal Hypoxia-Ischemia Induces Apoptotic and Excitotoxic Death of Periventricular White Matter Oligodendrocyte ProgenitorsSemantic proximity Read ↗

Prevalence and Prognostic Significance of Burst Suppression Patterns in Critically Ill Children - Comparison with Neurologically Healthy ControlsSemantic proximity Read ↗

Characterization of pontine neurons which respond to hypoxia in fetal sheep.Semantic proximity Read ↗

A physiologically-validated rat model of term birth asphyxia with seizure generation after, not during, brain hypoxiaSemantic proximity Read ↗

Plasticity in the phenotypic expression of catecholamines and vasoactive intestinal peptide in adult rat superior cervical and stellate ganglia after long-term hypoxia in vivo.Semantic proximity Read ↗

Effects of acute perinatal asphyxia in the rat hippocampus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.