Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular mechanisms underlying oncogenic RET fusion in lung adenocarcinoma.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 May 2014

Mizukami Tatsuji, Shiraishi Kouya, Shimada Yoko, Ogiwara Hideaki, Tsuta Koji, Ichikawa Hitoshi, Sakamoto Hiromi, Kato Mamoru, Shibata Tatsuhiro, Nakano Takashi, Kohno Takashi

Abstract excerpt

BACKGROUND: Oncogenic RET fusion, caused by an inversion in chromosome 10, was recently identified as a driver mutation for the development of lung adenocarcinoma (LADC). Nevertheless, the molecular mechanism(s) underlying the rearrangement of the RET locus during lung carcinogenesis are unknown....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Chromosome Breakpoints

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Inversion

Share to Cytoskeletal Proteins

Share to DNA End-Joining Repair

Share to Kinesins

Share to Oncogene Proteins, Fusion

Share to Proto-Oncogene Proteins c-ret

Source

Identifiers

PMID: 24722152
DOI: 10.1097/JTO.0000000000000135

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24722152-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular mechanisms underlying oncogenic RET fusion in lung adenocarcinoma.PMID 24722152Read ↗

The Genomic Characteristics of RET Fusion Positive Tumors in Chinese Non-Small Cell Lung Cancer (NSCLC) PatientsSemantic proximity Read ↗

Adversary of DNA integrity: a long non-coding RNA stimulates driver oncogenic chromosomal rearrangement in human thyroid cellsSemantic proximity Read ↗

Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression.Semantic proximity Read ↗

RET Fluorescence In Situ Hybridization Analysis Is a Sensitive but Highly Unspecific Screening Method for RET Fusions in Lung CancerSemantic proximity Read ↗

RET Fusion as a Novel Driver of Medullary Thyroid CarcinomaSemantic proximity Read ↗

KIF5B-RET Fusion gene may coincide oncogenic mutations of EGFR or KRAS gene in lung adenocarcinomas.Semantic proximity Read ↗

Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo.Semantic proximity Read ↗

Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancerSemantic proximity Read ↗

Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancerSemantic proximity Read ↗

KIF5B/RET fusion gene in surgically-treated adenocarcinoma of the lung.Semantic proximity Read ↗

Detection of RET (rearranged during transfection) variants and their downstream signal molecules in RET rearranged lung adenocarcinoma patients.Semantic proximity Read ↗

Identification of RET gene fusion by exon array analyses in “pan-negative” lung cancer from never smokersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.