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Article

Molecular mechanisms underlying oncogenic RET fusion in lung adenocarcinoma.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 May 2014

Mizukami Tatsuji, Shiraishi Kouya, Shimada Yoko, Ogiwara Hideaki, Tsuta Koji, Ichikawa Hitoshi, Sakamoto Hiromi, Kato Mamoru, Shibata Tatsuhiro, Nakano Takashi, Kohno Takashi

Abstract excerpt

BACKGROUND: Oncogenic RET fusion, caused by an inversion in chromosome 10, was recently identified as a driver mutation for the development of lung adenocarcinoma (LADC). Nevertheless, the molecular mechanism(s) underlying the rearrangement of the RET locus during lung carcinogenesis are unknown. METHODS: Genomic segments containing breakpoint junctions for RET fusions were cloned and analyzed by genomic...

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Identifiers

PMID: 24722152
DOI: 10.1097/JTO.0000000000000135

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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